The first episode of Lizzie McGuire premiered on TV ten years ago today on January 12, 2001.
I guess you could also say this is the ten year anniversary of Hilary Duff being famous, since Lizzie McGuire was her breakout role, although she did do some other stuff prior to Lizzie.
Looking back on the cast, no one really broke out anywhere close to Hilary's level of success, unfortunately. Lalaine recently had a small part in the hit movie Easy A, but really hadn't done much before that. Maybe she will resurface in some movies soon. Some of the other cast members have had small TV guest spots, but nothing really noteworthy.
Other than launching Hilary's career, I think the show also paved the way for subsequent popular Disney shows, especially Hannah Montana. Lizzie McGuire and The Lizzie McGuire Movie was a blueprint for what could be achieved by marketing the star of a fictional show as a real life pop star.